Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo

7 Jul 2017

Abstract excerpt

Previous studies have demonstrated that DNA methyltransferase 1 (DNMT1) is required for the maintenance of DNA methylation and epigenetic changes that may lead to the development of esophageal squamous cell carcinoma (ESCC). In order to investigate whether the silencing of DNMT1 protects tumor suppressor genes, including p16, and is able to be used as a potential therapy for human ESCC, short hairpin RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Esophageal and GI Pathology
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28927055
DOI: 10.3892/ol.2017.6535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivoPMID 28927055Read ↗

DNMT3A promotes the proliferation and metastasis of esophageal squamous cell carcinoma via upregulating HDAC9Semantic proximity Read ↗

The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinomaSemantic proximity Read ↗

miR-148a-3p Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting DNMT1Semantic proximity Read ↗

Promoter Methylation in Cytology Specimens as an Early Detection Marker for Esophageal Squamous Dysplasia and Early Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma.Semantic proximity Read ↗

p16, MGMT, RARβ2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesionsSemantic proximity Read ↗

Hypermethylation of multiple tumor-related genes associated with DMNT3b up-regulation served as a biomarker for early diagnosis of esophageal squamous cell carcinomaSemantic proximity Read ↗

Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma.Semantic proximity Read ↗

DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinomaSemantic proximity Read ↗

p16 INK4a hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Expression of DNA Methyltransferase 1 Is Activated by Hepatitis B Virus X Protein via a Regulatory Circuit Involving the p16INK4a-Cyclin D1-CDK 4/6-pRb-E2F1 PathwaySemantic proximity Read ↗

The role of DNMT1/hsa-miR-124-3p/BCAT1 pathway in regulating growth and invasion of esophageal squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.