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Article

Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells.

Journal of experimental & clinical cancer research : CR - 17 Oct 2011

Zhang Yi, Chen Fu-qiang, Sun Ye-hong, Zhou Shu-yan, Li Ti-yuan, Chen Rui

Abstract excerpt

BACKGROUND: DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a significant role in maintaining DNA methylation status and regulating the expression of tumor suppressor genes. The aim of this research was to investigate the relationship between DNMT1 and abnormal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 21999220
DOI: 10.1186/1756-9966-30-98
PMCID: PMC3207958

Genes

DNMT1
FHIT
CHFR
PTEN
CCNA1
PAX1
SFRP4

Provenance

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