Article
Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.
Molecular biology of the cell - 1 Apr 2005
Fournier Henri-Noël, Dupé-Manet Sandra, Bouvard Daniel, Luton Frédéric, Degani Simona, Block Marc R, Retta Saverio Francesco, Albiges-Rizo Corinne
Abstract excerpt
Integrin cytoplasmic domain-associated protein 1 (ICAP-1) has been shown to interact specifically with the beta1 integrin cytoplasmic domain and to control cell spreading on fibronectin. Interestingly, ICAP-1 also is observed in the nucleus, by immunocytochemical staining, and after biochemical cell fractionation, suggesting that it has additional roles that have yet to be determined. We show that the...
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