Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrins interact with focal adhesions through multiple distinct pathways.

Journal of cellular physiology - 1 Oct 1999

David F S, Zage P E, Marcantonio E E

Abstract excerpt

Integrin signaling involves oligomerization and a transmembrane conformational change induced by receptor occupancy. Previous work has shown that subsets of focal adhesion-associated proteins are recruited to integrins as a result of clustering, ligand binding, or both. However, it is unclear whether these discrete subsets reflect the differential binding of cytoplasmic proteins to the integrin or whether a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Adhesion Molecules
Share to Chickens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Integrins

Share to Phosphorylation

Share to Protein-Tyrosine Kinases

Source

Identifiers

PMID: 10457355
DOI: 10.1002/(SICI)1097-4652(199910)181:1<74::AID-JCP8>3.0.CO;2-H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrins interact with focal adhesions through multiple distinct pathways.PMID 10457355Read ↗

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.Semantic proximity Read ↗

Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.Semantic proximity Read ↗

Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1α) negatively regulates β1 integrins.Semantic proximity Read ↗

Mechanisms contributing to the activity of integrins on leukocytesSemantic proximity Read ↗

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.Semantic proximity Read ↗

Multiple factors contribute to integrin-talin interactions in vivo.Semantic proximity Read ↗

Integrin transmembrane signaling and cytoskeletal controlSemantic proximity Read ↗

Integrin traffic – the updateSemantic proximity Read ↗

Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.Semantic proximity Read ↗

beta1-integrin cytoplasmic subdomains involved in dominant negative function.Semantic proximity Read ↗

Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active.Semantic proximity Read ↗

Activation-enhanced alpha(IIb)beta(3)-integrin-cytoskeleton interactions outside of focal contacts require the alpha-subunit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.