Article
Gly16 + Glu27 beta2-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Mar 2005
Trombetta Ivani C, Batalha Luciana T, Rondon Maria U P B, Laterza Mateus C, Frazzatto Eliana, Alves Maria J N N, Santos Amilton C, Brum Patrícia C, Barretto Antonio C P, Halpern Alfredo, Villares Sandra M F, Negrão Carlos E
Abstract excerpt
We hypothesized that the muscle vasodilatation during mental stress and exercise would vary among humans who are polymorphic at alleles 16 and 27 of the beta(2)-adrenoceptors. From 216 preselected volunteers, we studied 64 healthy, middle-aged normotensive women selected to represent three genotypes: homozygous for the alleles Arg(16) and Gln(27) (Arg(16)/Gln(27), n = 34), Gly(16) and Gln(27) (Gly(16)/Gln(27), n...
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