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Article

Functional complementation of RNA interference mutants in trypanosomes.

BMC biotechnology - 9 Feb 2005

Rusconi Filippo, Durand-Dubief Mickaël, Bastin Philippe

Abstract excerpt

BACKGROUND: In many eukaryotic cells, double-stranded RNA (dsRNA) triggers RNA interference (RNAi), the specific degradation of RNA of homologous sequence. RNAi is now a major tool for reverse-genetics projects, including large-scale high-throughput screens. Recent reports have questioned the specificity of RNAi, raising problems in interpretation of RNAi-based experiments. RESULTS: Using the protozoan...

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Identifiers

PMID: 15703078
DOI: 10.1186/1472-6750-5-6
PMCID: PMC549545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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