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Article

Activation of STAT5-dependent transcription by the neurotrophin receptor Trk.

Journal of neurobiology - 1 May 2005

Klein Mathias, Hempstead Barbara L, Teng Kenneth K

Abstract excerpt

Neurotrophins exert many of their biological effects via the Trk receptor tyrosine kinases and require the regulated activation of distinct transcriptional and post-translational cellular events. Here we provide evidence for a novel signaling cascade from activated Trks to the transcription factor STAT5. Utilizing the STAT5 responsive element derived from the p21(WAF1/Cip1) promoter to modulate luciferase...

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Source

Identifiers

PMID: 15702476
DOI: 10.1002/neu.20124

Genes

JAK2
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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