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Article

Differential gene signature in adipose tissue depots of growth hormone transgenic mice.

Journal of neuroendocrinology - 1 Nov 2020

Duran-Ortiz Silvana, Young Jonathan A, Jara Adam, Jensen Elizabeth A, Basu Reetobrata, List Edward O, Qian Yanrong, Kopchick John J, Berryman Darlene E

Abstract excerpt

Bovine growth hormone (bGH) transgenic mice mimic the clinical condition of acromegaly, having high circulating growth hormone (GH) levels. These mice are giant, have decreased adipose tissue (AT) mass, impaired glucose metabolism and a shortened lifespan. The detrimental effects of excess GH have been suggested, in part, to be a result of its depot-specific actions on AT. To investigate this relationship, we...

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Identifiers

PMID: 33043505
DOI: 10.1111/jne.12893
PMCID: PMC7606825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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