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Article

Impaired hypothalamic regulation of endocrine function and delayed counterregulatory response to hypoglycemia in Magel2-null mice.

Endocrinology - 1 Mar 2011

Tennese Alysa A, Wevrick Rachel

Abstract excerpt

Hypothalamic dysfunction may underlie endocrine abnormalities in Prader-Willi syndrome (PWS), a genetic disorder that features GH deficiency, obesity, and infertility. One of the genes typically inactivated in PWS, MAGEL2, is highly expressed in the hypothalamus. Mice deficient for Magel2 are obe...

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Source

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Identifiers

PMID: 21248145
DOI: 10.1210/en.2010-0709
PMCID: PMC3198964

Genes

MAGEL2
GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21248145-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Impaired hypothalamic regulation of endocrine function and delayed counterregulatory response to hypoglycemia in Magel2-null mice.PMID 21248145Read ↗

Loss of magel2, a candidate gene for features of Prader-Willi syndrome, impairs reproductive function in mice.Semantic proximity Read ↗

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Hormonal Imbalances in Prader–Willi and Schaaf–Yang Syndromes Imply the Evolution of Specific Regulation of Hypothalamic Neuroendocrine Function in MammalsSemantic proximity Read ↗

The imprinted gene Magel2 regulates normal circadian output.Semantic proximity Read ↗

Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndromeSemantic proximity Read ↗

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuitsSemantic proximity Read ↗

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