IP-10 Mediates Selective Mononuclear Cell Accumulation and Activation in Response to Intrapulmonary Transgenic Expression and During Adenovirus-Induced Pulmonary Inflammation

Abstract excerpt

CXC chemokines that lack the glutamine-leucine-arginine (ELR) motif, including interferon (IFN)-inducible protein 10 (IP-10 or CXCL10), have been shown to mediate the generation of type 1 immune responses. In this study, we found that the intrapulmonary transient transgenic expression of murine IP-10 in mice using adenoviral gene transfer resulted in the early accumulation of neutrophils, natural killer (NK)...

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