Article
Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration.
The American journal of pathology - 1 Nov 2006
Yasuoka Hidekata, Zhou Zhihong, Pilewski Joseph M, Oury Tim D, Choi Augustine M K, Feghali-Bostwick Carol A
Abstract excerpt
We have recently shown that insulin-like growth factor-binding protein (IGFBP)-5 is overexpressed in idiopathic pulmonary fibrosis lung tissues and increases collagen and fibronectin deposition. Here, we further examined the effect of IGFBP-5 in vivo by intratracheal administration of replication-deficient adenovirus expressing human IGFBP-5 (Ad5), IGFBP-3 (Ad3), or no cDNA (cAd) to wild-type mice. Increased...
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