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Article

Viral Capsid Is a Pathogen-Associated Molecular Pattern in Adenovirus Keratitis

15 Apr 2010

Abstract excerpt

Human adenovirus (HAdV) infection of the human eye, in particular serotypes 8, 19 and 37, induces the formation of corneal subepithelial leukocytic infiltrates. Using a unique mouse model of adenovirus keratitis, we studied the role of various virus-associated molecular patterns in subsequent innate immune responses of resident corneal cells to HAdV-37 infection. We found that neither viral DNA, viral gene...

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PMID: 20419141
DOI: 10.1371/journal.ppat.1000841

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