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Article

Intrapulmonary IFN-beta gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung.

Cancer research - 15 Sept 2005

Wilderman Michael J, Sun Jing, Jassar Arminder S, Kapoor Veena, Khan Mohamed, Vachani Anil, Suzuki Eiji, Kinniry Paul A, Sterman Daniel H, Kaiser Larry R, Albelda Steven M

Abstract excerpt

Given previous work showing that an adenoviral vector expressing IFN-beta (Ad.IFNbeta) was highly effective in eradicating i.p. mesothelioma tumors, the antitumor efficacy of this agent was evaluated in an orthotopic model of bronchogenic adenocarcinoma of the lung. These transgenic mice have a conditionally expressed, oncogenic K-rasG12D allele that can be activated by intratracheal administration of an...

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PMID: 16166316
DOI: 10.1158/0008-5472.CAN-05-0920

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