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Article

Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid hormone receptor beta.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995

Nawaz Z, Tsai M J, O'Malley B W

Abstract excerpt

Although most nuclear hormone receptors are ligand-dependent transcriptional activators, certain members of this superfamily, such as thyroid hormone receptor (TR) and retinoic acid receptor (RAR), are involved in transcriptional repression. The silencing function of these receptors has been localized to the ligand binding domain (LBD). Previously, we demonstrated that overexpression of either the entire LBD or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8524830
DOI: 10.1073/pnas.92.25.11691
PMCID: PMC40468

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid hormone receptor beta.PMID 8524830Read ↗

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