Article
Transgenic oncogene mice. Tumor phenotype predicts genotype.
The American journal of pathology - 1 Sept 1991
Cardiff R D, Sinn E, Muller W, Leder P
Abstract excerpt
The hypothesis that oncogenes influence tumor phenotype was tested by examining slides from 607 mammary tumors from 407 transgenic mice bearing the ras, myc, and/or neu oncogenes. Most tumors (91%) had patterns (phenotypes) that could not be classified by Dunn's standard nomenclature. The nonstandard tumors were described as eosinophilic small cell (SC), basophilic large cell (LC), or pale intermediate cell (IC)....
Topics
- Animals
- Genes, myc
- Genes, ras
- Genotype
- Mammary Neoplasms, Experimental
- Mice
- Mice, Transgenic
- Oncogenes
- Phenotype