Article
Sources of variability in data from a lacI transgenic mouse mutation assay.
Environmental and molecular mutagenesis - 1 Jan 1994
Piegorsch W W, Lockhart A M, Margolin B H, Tindall K R, Gorelick N J, Short J M, Carr G J, Thompson E D, Shelby M D
Abstract excerpt
Experimental features of a transgenic mouse mutation assay based on a lacI target transgene from Escherichia coli are considered in detail. Sources of variability in the experimental protocol that can affect the statistical nature of the observations are examined with the goal of identifying sour...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Analysis of Variance
- Animals
- Binomial Distribution
- Chi-Square Distribution
- DNA Damage
- DNA Mutational Analysis
- Escherichia coli
- Genetic Variation
- Hydroxyurea
- Lac Operon
- Liver
- Logistic Models
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenesis, Site-Directed