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Article

Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies.

Toxicology and applied pharmacology - 15 Feb 2005

Spiegelstein Ofer, Gould Amy, Wlodarczyk Bogdan, Tsie Marlene, Lu Xiufen, Le Chris, Troen Aron, Selhub Jacob, Piedrahita Jorge A, Salbaum J Michael, Kappen Claudia, Melnyk Stepan, James Jill, Finnell Richard H

Abstract excerpt

Previous studies have demonstrated that mice lacking a functional folate binding protein 2 gene (Folbp2-/-) were significantly more sensitive to in utero arsenic exposure than were the wild-type mice similarly exposed. When these mice were fed a folate-deficient diet, the embryotoxic effect of arsenate was further exacerbated. Contrary to expectations, studies on 24-h urinary speciation of sodium arsenate did not...

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Identifiers

PMID: 15694460
DOI: 10.1016/j.taap.2004.07.006
PMCID: PMC3938173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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