Article
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.
The American journal of clinical nutrition - 1 Nov 2016
Christensen Karen E, Hou Wenyang, Bahous Renata H, Deng Liyuan, Malysheva Olga V, Arning Erland, Bottiglieri Teodoro, Caudill Marie A, Jerome-Majewska Loydie A, Rozen Rima
Abstract excerpt
BACKGROUND: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of elevated folic acid intake. OBJECTIVES: We investigated the effects of...
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