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Article

Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity.

Toxicology and applied pharmacology - 15 Feb 2014

Wlodarczyk Bogdan J, Zhu Huiping, Finnell Richard H

Abstract excerpt

BACKGROUND: In utero exposure to arsenic is known to adversely affect reproductive outcomes. Evidence of arsenic teratogenicity varies widely and depends on individual genotypic differences in sensitivity to As. In this study, we investigated the potential interaction between 5,10-methylenetetrahydrofolate reductase (Mthfr) genotype and arsenic embryotoxicity using the Mthfr knockout mouse model. METHODS:...

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Source

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Identifiers

PMID: 24384392
DOI: 10.1016/j.taap.2013.12.014
PMCID: PMC3943866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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