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Article

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.

Cell cycle (Georgetown, Tex.) - 1 Oct 2016

Cukras Scott, Lee Euiho, Palumbo Emily, Benavidez Pamela, Moldovan George-Lucian, Kee Younghoon

Abstract excerpt

USP1 deubiquitinating enzyme and its stoichiometric binding partner UAF1 play an essential role in promoting DNA homologous recombination (HR) repair in response to various types of DNA damaging agents. Deubiquitination of FANCD2 may be attributed to the key role of USP1-UAF1 complex in regulating HR repair, however whether USP1-UAF1 promotes HR repair independently of FANCD2 deubiquitination is not known. Here...

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Source

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Identifiers

PMID: 27463890
DOI: 10.1080/15384101.2016.1209613
PMCID: PMC5053553

Genes

USP1
FANCD2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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