Article
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.
Molecular cell - 14 Dec 2007
Cohn Martin A, Kowal Przemyslaw, Yang Kailin, Haas Wilhelm, Huang Tony T, Gygi Steven P, D'Andrea Alan D
Abstract excerpt
The deubiquitinating enzyme USP1 controls the cellular levels of the DNA damage response protein Ub-FANCD2, a key protein of the Fanconi anemia DNA repair pathway. Here we report the purification of a USP1 multisubunit protein complex from HeLa cells containing stoichiometric amounts of a WD40 repeat-containing protein, USP1 associated factor 1 (UAF1). In vitro reconstitution of USP1 deubiquitinating enzyme...
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