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Article

Phase I Study of Recombinant Human Endostatin in Patients With Advanced Solid Tumors

12 Sept 2002

Abstract excerpt

PURPOSE: Endostatin, a 20-kd fragment of collagen XVIII, is a potent inhibitor of angiogenesis. We evaluated recombinant human endostatin (rh-Endo) in a phase I trial designed to assess safety, pharmacokinetics, and serum markers of angiogenesis in patients with solid tumors. PATIENTS AND METHODS: Twenty-six patients were enrolled onto a dose-finding trial of rh-Endo administered as an intravenous bolus over a...

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Identifiers

PMID: 12228199
DOI: 10.1200/jco.2002.11.061

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