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Article

Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1.

The Journal of biological chemistry - 10 May 2002

Hanai Jun-ichi, Dhanabal Mohan, Karumanchi S Ananth, Albanese Chris, Waterman Matthew, Chan Barden, Ramchandran Ramani, Pestell Richard, Sukhatme Vikas P

Abstract excerpt

Endostatin, a type XVIII collagen fragment, is a potent antiangiogenic molecule that inhibits endothelial cell migration, promotes apoptosis, and induces cell cycle arrest in vitro. We have investigated the mechanism by which endostatin causes G(1) arrest in endothelial cells. Endostatin decreased the hyperphosphorylated retinoblastoma gene product and down-regulated cyclin D1 mRNA and protein. Importantly,...

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Source

Identifiers

PMID: 11815623
DOI: 10.1074/jbc.M112274200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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