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Article

Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa

1 Aug 1999

Abstract excerpt

Serum levels of interleukin-10 (IL-10) are elevated in a proportion of patients with untreated chronic hepatitis C, and this may compromise the host immune response to the virus. The capacity for IL-10 production varies according to the genetic composition of the IL-10 locus. We examined the inheritance of 3 biallelic polymorphisms in the IL-10 gene promoter in patients with chronic hepatitis C and their...

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PMID: 10421663
DOI: 10.1002/hep.510300207

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