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Article

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

Molecular and cellular neurosciences - 1 Feb 2005

Klugmann Matthias, Symes C Wymond, Leichtlein Claudia B, Klaussner Bettina K, Dunning Jane, Fong Dahna, Young Deborah, During Matthew J

Abstract excerpt

Homer proteins mediate molecular rearrangements leading to changes in spine morphology. This points to a role of Homer in learning and memory. Homer 1c features both the ligand binding domain and a coiled-coiled domain for self-multimerization. Homer 1a lacks the coiled-coiled domain. Here, we report a new isoform which we termed 1g, lacking the Homer ligand binding domain. We dissected the functional roles of...

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Identifiers

PMID: 15691715
DOI: 10.1016/j.mcn.2004.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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