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Article

The role of the amino acid residue at alpha1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors.

British journal of pharmacology - 1 Apr 2007

Purohit P G, Tate R J, Pow E, Hill D, Connolly J G

Abstract excerpt

BACKGROUND AND PURPOSE: Nicotinic acetylcholine receptors (AChRs) are valuable therapeutic targets. To exploit them fully requires rapid assays for the evaluation of potentially therapeutic ligands and improved understanding of the interaction of such ligands with their receptor binding sites. EXPERIMENTAL APPROACH: A variety of neuromuscular blocking agents (NMBAs) were tested for their ability to inhibit the...

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Identifiers

PMID: 17293883
DOI: 10.1038/sj.bjp.0707156
PMCID: PMC2013881

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Source receipt: pubmed, retrieved 7 Sept 2026.

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