Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor.

The American journal of physiology - 1 Mar 1994

O'Leary M E, Filatov G N, White M M

Abstract excerpt

d-Tubocurarine (curare) is a well-characterized competitive antagonist of nicotinic acetylcholine receptors (AChRs), and it is usually assumed that curare and agonists share a common binding site. We have examined the role of several highly conserved residues of the alpha-, gamma-, and delta-subunits in the interaction of curare with the Torpedo acetylcholine receptor (AChR). Curare inhibition of wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Dose-Response Relationship, Drug
Share to Electric Conductivity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Oocytes

Share to Receptors, Cholinergic

Share to Torpedo

Share to Xenopus laevis

Source

Identifiers

PMID: 8166227
DOI: 10.1152/ajpcell.1994.266.3.C648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor.PMID 8166227Read ↗

Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function.Semantic proximity Read ↗

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.Semantic proximity Read ↗

Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain.Semantic proximity Read ↗

Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis.Semantic proximity Read ↗

Interaction of d-tubocurarine analogs with mutant 5-HT(3) receptors.Semantic proximity Read ↗

Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors.Semantic proximity Read ↗

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors.Semantic proximity Read ↗

The role of the amino acid residue at alpha1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors.Semantic proximity Read ↗

Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing.Semantic proximity Read ↗

The effect of unliganded gating on agonist response in nicotinic receptors.Semantic proximity Read ↗

Modification of wild-type and batrachotoxin-resistant muscle mu1 Na+ channels by veratridine.Semantic proximity Read ↗

Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.