Article
Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor.
The American journal of physiology - 1 Mar 1994
O'Leary M E, Filatov G N, White M M
Abstract excerpt
d-Tubocurarine (curare) is a well-characterized competitive antagonist of nicotinic acetylcholine receptors (AChRs), and it is usually assumed that curare and agonists share a common binding site. We have examined the role of several highly conserved residues of the alpha-, gamma-, and delta-subunits in the interaction of curare with the Torpedo acetylcholine receptor (AChR). Curare inhibition of wild-type...
Topics
- Animals
- Binding Sites
- Curare
- Dose-Response Relationship, Drug
- Electric Conductivity
- Mutation
- Oocytes
- Receptors, Cholinergic
- Torpedo
- Tubocurarine
- Xenopus laevis