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Article

Docking is not a prerequisite but a temporal constraint for fusion of secretory granules.

Traffic (Copenhagen, Denmark) - 1 Jul 2008

Kasai Kazuo, Fujita Takuji, Gomi Hiroshi, Izumi Tetsuro

Abstract excerpt

We examined secretory granule dynamics using total internal reflection fluorescence microscopy in normal pancreatic beta cells and their mutants devoid of Rab27a and/or its effector, granuphilin, which play critical roles in the docking and recruitment of insulin granules to the plasma membrane. In the early phase of glucose stimulation in wild-type cells, we observed marked fusion of granules recruited from a...

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Identifiers

PMID: 18397364
DOI: 10.1111/j.1600-0854.2008.00744.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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