Article
CD36 is a sensor of diacylglycerides.
Nature - 3 Feb 2005
Hoebe Kasper, Georgel Philippe, Rutschmann Sophie, Du Xin, Mudd Suzanne, Crozat Karine, Sovath Sosathya, Shamel Louis, Hartung Thomas, Zähringer Ulrich, Beutler Bruce
Abstract excerpt
Toll-like receptor 2 (TLR2) is required for the recognition of numerous molecular components of bacteria, fungi and protozoa. The breadth of the ligand repertoire seems unusual, even if one considers that TLR2 may form heteromers with TLRs 1 and 6 (ref. 12), and it is likely that additional proteins serve as adapters for TLR2 activation. Here we show that an N-ethyl-N-nitrosourea-induced nonsense mutation of Cd36...
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