Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.

Abstract excerpt

Classical genetic methods, driven by phenotype rather than hypotheses, generally permit the identification of all proteins that serve nonredundant functions in a defined biological process. Long before this goal is achieved, and sometimes at the very outset, genetics may cut to the heart of a biological puzzle. So it was in the field of mammalian innate immunity. The positional cloning of a spontaneous mutation...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ethylnitrosourea
• Share to Infections