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Article

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2009

Xiao Nengming, Eidenschenk Celine, Krebs Philippe, Brandl Katharina, Blasius Amanda L, Xia Yu, Khovananth Kevin, Smart Nora G, Beutler Bruce

Abstract excerpt

Sluggish was identified in a population of third generation mice descended from N-ethyl-N-nitrosourea-mutagenized sires. Macrophages from homozygotes exhibited impaired TNF-alpha production in response to all TLR ligands tested and displayed impaired type I IFN production in response to TLR7 and TLR9 stimulations. The phenotype was confined to a critical region on mouse chromosome 18 and then ascribed to a T to A...

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Source

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Identifiers

PMID: 19923465
DOI: 10.4049/jimmunol.0902718
PMCID: PMC8424661

Genes

TNF
TLR7
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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