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Article

Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.

Development (Cambridge, England) - 1 Mar 2005

Leight Elizabeth R, Glossip Danielle, Kornfeld Kerry

Abstract excerpt

The LIN-1 ETS transcription factor inhibits vulval cell fates during Caenorhabditis elegans development. We demonstrate that LIN-1 interacts with UBC-9, a small ubiquitin-related modifier (SUMO) conjugating enzyme. This interaction is mediated by two consensus sumoylation motifs in LIN-1. Biochemical studies showed that LIN-1 is covalently modified by SUMO-1. ubc-9 and smo-1, the gene encoding SUMO-1, inhibit...

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Identifiers

PMID: 15689373
DOI: 10.1242/dev.01664

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UBC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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