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Article

Zinc protects against arsenic-induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Dec 2004

Milton Austin Graham, Zalewski Peter David, Ratnaike Ranjit Nihal

Abstract excerpt

Acute and chronic arsenic exposure results in toxicity in humans and causes many neurological and other manifestations. For the first time the present study reports that zinc decreases arsenic-induced apoptosis and also confirms a single report of apoptosis induced by arsenic in a neuronal cell line. Apoptosis measured by DEVD-caspase activity peaked between 10 microM and 20 microM of arsenic trioxide. Higher...

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Identifiers

PMID: 15689113
DOI: 10.1007/s10534-004-1210-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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