Article
Zinc-induced neuronal death in cortical neurons.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Jun 2000
Lobner D, Canzoniero L M, Manzerra P, Gottron F, Ying H, Knudson M, Tian M, Dugan L L, Kerchner G A, Sheline C T, Korsmeyer S J, Choi D W
Abstract excerpt
Although Zn2+ is normally stored and released in the brain, excessive exposure to extracellular Zn2+ can be neurotoxic. The purpose of the present study was to determine the type of neuronal cell death, necrosis versus apoptosis, induced by Zn2+ exposure. Addition of 10-50 microM ZnCl2 to the bathing medium of murine neuronal and glial cell cultures induced, over the next 24 hrs., Zn2+-concentration-dependent...
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