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Article

High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations.

International journal of radiation oncology, biology, physics - 1 Sept 2007

Imaoka Tatsuhiko, Nishimura Mayumi, Kakinuma Shizuko, Hatano Yukiko, Ohmachi Yasushi, Yoshinaga Shinji, Kawano Akihiro, Maekawa Akihiko, Shimada Yoshiya

Abstract excerpt

PURPOSE: The high relative biologic effectiveness (RBE) of high-linear energy transfer (LET) heavy-ion radiation has enabled powerful radiotherapy. The potential risk of later onset of secondary cancers, however, has not been adequately studied. We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model. METHODS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17707273
DOI: 10.1016/j.ijrobp.2007.05.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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