Article
Diagnosis of HNF-1alpha mutations on a PNA zip-code microarray by single base extension.
Nucleic acids research - 1 Feb 2005
Song Jae Yang, Park Hyun Gyu, Jung Sung-Ouk, Park JaeChan
Abstract excerpt
In the present study, we exploited the superior features of peptide nucleic acids (PNAs) to develop an efficient PNA zip-code microarray for the detection of hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations that cause type 3 maturity onset diabetes of the young (MODY). A multi-epoxy linker compound was synthesized and used to achieve an efficient covalent linking of amine-modified PNA to an aminated glass...
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