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Article

Quantitative detection of single base mutation by combining PNA hybridization and MALDI-TOF mass analysis.

Chemical communications (Cambridge, England) - 8 May 2013

Yeo Youn Jee, Roh Kyoungmin, Bang Joo Young, Lee Eun Hee, Park Hyung Soon, Kim Dong-Eun

Abstract excerpt

Peptide nucleic acid (PNA) probes were designed to bind to the internal reference sequence and the single base mutation sequence within PCR-amplified DNA templates. PNAs hybridized to the target sequences on DNA were analyzed using MALDI-TOF mass spectrometry. Accurate quantification of the relative amount of mutant DNA was reproducibly demonstrated.

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PMID: 23536008
DOI: 10.1039/c3cc00070b

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