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Article

Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection.

Organic & biomolecular chemistry - 16 Aug 2017

Gahtory Digvijay, Murtola Merita, Smulders Maarten M J, Wennekes Tom, Zuilhof Han, Strömberg Roger, Albada Bauke

Abstract excerpt

In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows various PNA-based detection strategies. Firstly, a thiazole orange (TO) clicked PNA probe facilitates a binary readout when combined with F/Q labeled DNA, giving increased sensitivity for antisense detection. Secondly, our TO-PNA conjugate also allows single nucleotide...

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PMID: 28766647
DOI: 10.1039/c7ob01592e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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