Article
Essential genes in proximal 3L heterochromatin of Drosophila melanogaster.
Molecular & general genetics : MGG - 1 Feb 2001
Schulze S, Sinclair D A, Silva E, Fitzpatrick K A, Singh M, Lloyd V K, Morin K A, Kim J, Holm D G, Kennison J A, Honda B M
Abstract excerpt
We have further characterized essential loci within the centric heterochromatin of the left arm of chromosome 3 (3L) of Drosophila melanogaster, using EMS, radiation and P element mutagenesis. We failed to find any new essential genes, a result that suggests a lower-than-average gene density in this region. Mutations affecting expression of the most proximal gene [lethal 1, l1 or l(3)80Fj] act as dominant...
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