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Article

PIG-A mutations in normal hematopoiesis.

Blood - 15 May 2005

Hu Rong, Mukhina Galina L, Piantadosi Steven, Barber Jamie P, Jones Richard J, Brodsky Robert A

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is caused by phosphatidylinositol glycan-class A (PIG-A) mutations in hematopoietic stem cells (HSCs). PIG-A mutations have been found in granulocytes from most healthy individuals, suggesting that these spontaneous PIG-A mutations are important in the pathogenesis of PNH. It remains unclear if these PIG-A mutations have relevance to those found in PNH. We isolated CD34+...

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Identifiers

PMID: 15687243
DOI: 10.1182/blood-2004-04-1472
PMCID: PMC1895084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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