Role of phosphatidylinositol-linked proteins in paroxysmal nocturnal hemoglobinuria pathogenesis.

doi:10.1146/annurev.med.47.1.1

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Article

Role of phosphatidylinositol-linked proteins in paroxysmal nocturnal hemoglobinuria pathogenesis.

Annual review of medicine - 1 Jan 1996

Kinoshita T, Inoue N, Takeda J

Abstract excerpt

Patients with paroxysmal nocturnal hemoglobinuria have one or more mutant hematopoietic stem cell clones deficient in glycosylphosphatidylinositol (GPI)-anchor synthesis owing to somatic mutations in the X-linked gene PIG-A. The progeny of mutant stem cells dominates the peripheral blood. The pre...

Topics

Erythrocytes
Genetic Linkage
Glycosylphosphatidylinositols
Hematopoietic Stem Cells
Hemoglobinuria, Paroxysmal
Hemolysis
Humans
Membrane Proteins
Mutation
Phosphatidylinositols
Sex Chromosome Aberrations
X Chromosome

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