Article
Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria.
Blood - 15 Nov 2002
Kai Tatsuyuki, Shichishima Tsutomu, Noji Hideyoshi, Yamamoto Tetsuo, Okamoto Masatoshi, Ikeda Kazuhiko, Maruyama Yukio
Abstract excerpt
To define the phosphatidylinositol glycan-class A (PIG-A) gene abnormality in precursor cells and the changes of expression of glycosylphosphatidylinositol-anchored protein and contribution of paroxysmal nocturnal hemoglobinuria (PNH) clones with PIG-A gene abnormalities among various cell lineages during differentiation and maturation, we investigated CD59 expression on bone marrow CD34(+) cells and peripheral...
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