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Article

Paroxysmal nocturnal hemoglobinuria: An acquired genetic disease.

American journal of hematology - 1 Nov 1999

Nishimura J, Murakami Y, Kinoshita T

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by an intravascular hemolytic anemia. Abnormal blood cells lack a series of glycosylphosphatidylinositol (GPI)-anchored proteins. The lack of GPI-anchored complement regulatory proteins, such as decay-accelerating factor (DAF) and CD59, results in complement-mediated hemolysis and hemoglobinuria. In the...

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Source

Identifiers

PMID: 10539884
DOI: 10.1002/(sici)1096-8652(199911)62:3<175::aid-ajh7>3.0.co;2-8

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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