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Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the <i>pfmdr1</i> gene of <i>Plasmodium falciparum</i>

1 May 2000

Abstract excerpt

The declining efficacy of chloroquine and pyrimethamine/sulphadoxine in the treatment of human malaria has led to the use of newer antimalarials such as mefloquine and artemisinin. Sequence polymorphisms in the pfmdr1 gene, the gene encoding the plasmodial homologue of mammalian multidrug resistance transporters, have previously been linked to resistance to chloroquine in some, but not all, studies. In this...

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Identifiers

PMID: 10844681
DOI: 10.1046/j.1365-2958.2000.01914.x

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