Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Near-diploid and near-triploid human sporadic colorectal adenocarcinomas differ for KRAS2 and TP53 mutational status.

Genes, chromosomes & cancer - 1 Jun 2003

Giaretti Walter, Venesio Tiziana, Sciutto Andrea, Prevosto Claudia, Geido Elio, Risio Mauro

Abstract excerpt

Mutations of the KRAS2 protoncogene and inactivation of the TP53 oncosuppressor gene have been suggested to contribute to chromosomal instability (CIN) and aneuploidy in colorectal cancer (CRC). Previous work has also shown that the degree of DNA ploidy [DNA index (DI)], as obtained by flow cytometry in CRC, is non-randomly distributed and, in particular, that DI near-diploid and near-triploid values are well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diploidy

Share to Genes, p53

Share to Polyploidy

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Identifiers

PMID: 12696070
DOI: 10.1002/gcc.10203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Near-diploid and near-triploid human sporadic colorectal adenocarcinomas differ for KRAS2 and TP53 mutational status.PMID 12696070Read ↗

Combined DNA flow cytometry and sorting with k-ras2 mutation spectrum analysis and the prognosis of human sporadic colorectal cancer.Semantic proximity Read ↗

KRAS, p53 and BRAF gene mutations and aneuploidy in sporadic colorectal cancer progression.Semantic proximity Read ↗

Tumor progression by dna flow cytometry in human colorectal cancerSemantic proximity Read ↗

Chromosomal instability and APC gene mutations in human sporadic colorectal adenomas.Semantic proximity Read ↗

DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease‐associated serrated epithelial change and traditional serrated adenomasSemantic proximity Read ↗

Analysis of Ki-ras gene mutations associated with DNA diploid, aneuploid, and multiploid colorectal carcinomas using a crypt isolation technique.Semantic proximity Read ↗

p53 mutations and DNA ploidy in colorectal adenocarcinomas.Semantic proximity Read ↗

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer.Semantic proximity Read ↗

Chromosomal instability, aneuploidy, and gene mutations in human sporadic colorectal adenomas.Semantic proximity Read ↗

The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma.Semantic proximity Read ↗

Relationship between genetic alterations and prognosis in sporadic colorectal cancerSemantic proximity Read ↗

DNA Ploidy Abnormalities in Basal and Superficial Regions of the Crypts in Barrett's Esophagus and Associated Neoplastic LesionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.