Article
Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter.
The Journal of biological chemistry - 23 Mar 2007
Gawenis Lara R, Bradford Emily M, Prasad Vikram, Lorenz John N, Simpson Janet E, Clarke Lane L, Woo Alison L, Grisham Christina, Sanford L Philip, Doetschman Thomas, Miller Marian L, Shull Gary E
Abstract excerpt
The NBC1 Na+/HCO3- cotransporter is expressed in many tissues, including kidney and intestinal epithelia. NBC1 mutations cause proximal renal tubular acidosis in humans, consistent with its role in HCO3- absorption in the kidney. In intestinal and colonic epithelia, NBC1 localizes to basolateral membranes and is thought to function in anion secretion. To test the hypothesis that NBC1 plays a role in...
Topics
- Acidosis
- Aldosterone
- Animals
- Anions
- Colon
- Cyclic AMP
- Intestinal Mucosa
- Kidney
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Phenotype
- Phosphorylation
- Sodium