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Article

Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling.

The Journal of biological chemistry - 8 Aug 2003

Tarui Takehiko, Andronicos Nicholas, Czekay Ralf-Peter, Mazar Andrew P, Bdeir Khalil, Parry Graham C, Kuo Alice, Loskutoff David J, Cines Douglas B, Takada Yoshikazu

Abstract excerpt

Urokinase-type plasminogen activator (uPA) induces cell adhesion and chemotactic movement. uPA signaling requires its binding to uPA receptor (uPAR/CD87), but how glycosylphosphatidylinositol-anchored uPAR mediates signaling is unclear. uPAR is a ligand for several integrins (e.g. alpha 5 beta 1)...

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Identifiers

PMID: 12754207
DOI: 10.1074/jbc.M304694200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12754207-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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