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Article

Crystal structure of the urokinase receptor in a ligand-free form.

Journal of molecular biology - 9 Mar 2012

Xu Xiang, Gårdsvoll Henrik, Yuan Cai, Lin Lin, Ploug Michael, Huang Mingdong

Abstract excerpt

The urokinase receptor urokinase-type plasminogen activator receptor (uPAR) is a surface receptor capable of not only focalizing urokinase-type plasminogen activator (uPA)-mediated fibrinolysis to the pericellular micro-environment but also promoting cell migration and chemotaxis. Consistent with this multifunctional role, uPAR binds several extracellular ligands, including uPA and vitronectin. Structural studies...

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Source

Identifiers

PMID: 22285761
DOI: 10.1016/j.jmb.2011.12.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of the urokinase receptor in a ligand-free form.PMID 22285761Read ↗

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