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Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes.

Annual review of pharmacology and toxicology - 23 Jan 2024

Tremmel Roman, Hofmann Ute, Haag Mathias, Schaeffeler Elke, Schwab Matthias

Abstract excerpt

Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic information of absorption, distribution, metabolism, and excretion (ADME) targets such as drug-metabolizing enzymes or transporters to predict differences in the patient's phenotype. However, there is evidence that the phenotype-genotype...

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PMID: 37585662
DOI: 10.1146/annurev-pharmtox-032023-121106

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