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Article

Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.

Journal of clinical pharmacology - 1 Jul 2016

Momper Jeremiah D, Tsunoda Shirley M, Ma Joseph D

Abstract excerpt

Drug transporters are present in various tissues and have a significant role in drug absorption, distribution, and elimination. The International Transporter Consortium has identified 7 transporters of increasing importance from evidence of clinically significant transporter-mediated drug-drug interactions. The transporters are P-glycoprotein, breast cancer resistance protein, organic anion transporting...

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PMID: 27385182
DOI: 10.1002/jcph.736

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